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Raw Flibanserin hmoov (167933-07-5)

nyob 5.00 tawm ntawm 5 raws li nyob rau hauv 1 neeg ntsuam xyuas
(1 neeg saib xyuas)

Raw Flibanserin hmoov yog ib hom tshuaj siv tshuaj rau kev kho mob ntawm cov poj niam premenopausal uas tau txais, kev sib daj sib deev tsis zoo siab ....


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 25kg / Nruas
Peev Xwm: 1489kg / hli

Hauj lwm

Raw Flibanserin hmoov (167933-07-5) video

Raw Flibanserin hmoov (167933-07-5)

Raw Flibanserin hmoov, muag nyob rau hauv lub npe Trade Addyi, yog ib hom tshuaj ntau yam kabmob serotonin agonist thiab antagonist uas yog siv rau kev kho mob ua ntej menopausal cov poj niam nrog kev sib deev tsis siab ntsig txog kev sib deev (HSDD). Cov tshuaj noj kom ntau ntxiv rau cov kev sib deev hauv ib lub hlis los ntawm ib nrab ntawm cov placebo los ntawm qhov pib ntawm ob txog rau peb. Tib lub sij hawm, Nws muaj lub luag hauj lwm raws li serotonergic agonist, serotonergic antagonist thiab antidepressant ..

Raw Flibanserin hmoov (167933-07-5) Specifications

khoom npe Raw Flibanserin hmoov
Tshuaj Npe Tshuaj 1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one
Hom NAme Addyi
Chav Kawm Tshuaj Multifunctional serotonin agonist thiab antagonist
CAS Number 167933-07-5
Hauv Chikey PPRRDFIXUUSXRA-UHFFFAOYSA-N
molecular Formula C20H21F3N4O
molecular Wyim 390.41 g / mol
Monoisotopic pawg 390.167 g / mol
Melting Point 225 ° C
kub Point N / A
Loj Ib Nrab Ntawm Ib Leeg ~ 11 teev
xim Dawb rau beige
Solubility DMSO: soluble10mg / mL, ntshiab
Snkauj Thuab cua 2-8 ° C
Raw Flibanserin hmoov Application Tsim los kho cov kev sib deev hypoactive ntshaw tsis meej rau cov poj niam

Raw Flibanserin hmoov (167933-07-5) Description

Flibanserin hmoov yog thawj cov tshuaj yuav tsum tau txais kev pom zoo rau kev sib daj sib deev tsis siab ntsws (HSDD) hauv cov poj niam premenopausal los ntawm FDA hauv lub Xya hli 2015. Nws yog Ameslikas tsim raws li kev noj tshuaj antidepressant by Boehringer Ingelheim, tab sis tsom tsis muaj kev cuam tshuam rau cov kev sim thiab tau tsim ntxiv ua ib qho kev sib daj sib deev kev tsis sib haum xeeb los ntawm Sprout Pharmaceuticals. Flibanserin lub tswv yim ntawm kev ua haujlwm yog raug rau nws qhov kev siab siab rau 5-HTA1 thiab 5-HTA2 receptors, tso cov kev ua rau agonist ntawm 5-HTA1 thiab antagonist ntawm 5-HTA2, uas ua rau txo qis ntawm serotonin nyob rau hauv lub hlwb thiab raws li ib qho kev cuam tshuam ntawm nce norepinephrine thiab dopamine neurotransmitters.

Flibanserin hmoov (167933-07-5) Mechanism of Action

Flibanserin lub tswv yim ntawm kev ua haujlwm yog raug rau nws qhov kev siab siab rau 5-HTA1 thiab 5-HTA2 receptors, tso cov kev ua rau agonist ntawm 5-HTA1 thiab antagonist ntawm 5-HTA2, uas ua rau txo qis ntawm serotonin nyob rau hauv lub hlwb thiab raws li ib qho kev cuam tshuam ntawm nce norepinephrine thiab dopamine neurotransmitters. Flibansetrin muaj high affinity rau serotonin receptors hauv lub hlwb: nws ua raws li tus agonist ntawm 5-HT1A thiab ib antagonist ntawm 5-HT2A. Hauv vivo, flibanserin sib npaug rau 5-HT1A thiab 5-HT2A receptors. Txawm li cas los xij, nyob hauv siab siab hlwb 5-HT (ie, nyob hauv kev nyuab siab), flibanserin tej zaum yuav nyob 5-HT2A receptors hauv feem ntau dua 5-HT (1A) receptors. Tej zaum nws kuj mob qoob loo tiv thaiv D4 (dopamine) receptors thiab 5-HT2B thiab 5-HTB2C. Nws cov kev txiav txim rau neurotransmitter receptors yuav ua rau kom txo tau cov kab mob hauv serotonin thiab nce hauv dopamine thiab norepinephrine ntau ntau, tag nrho cov uas yuav ua tau ib feem hauv kev ua nqi zog. Flibanserin muag nyob rau hauv lub npe ntawm Addyi thiab qhia rau kev kho mob ntawm cov poj niam premenopausal nrog nrhiav, HS tsis pom kev sib daj sib deev (HSDD) raws li cov tsis muaj kev sib deev uas ua rau muaj kev nyuaj siab lossis kev nyuaj siab.

Daim ntawv thov ntawm cov hmoov Flibanserin (167933-07-5)

Flibanserin hmoov yog ib 5-HT1A agonist thiab 5-HT2A antagonist uas yog tsim los kho cov poj niam tsis muaj siab tsis zoo hauv cov poj niam (1,2).

Pom zoo Flibanserin hmoov (167933-07-5)

100 mg ib zaug ib hnub ib zaug ntawm kev pw

Ntu kev siv tshuaj kho: Cov tshuaj no yuav tsum tsis ua haujlwm tom qab 8 lub limtiam yog tias tus neeg mob tsis qhia txog kev txhim kho hauv cov tsos mob.

Cov lus qhia: Cov tshuaj no tsis tau qhia los txhim kho kev sib deev, thiab tsis qhia rau kev kho mob hauv cov poj niam postmenopausal lossis cov txiv neej.

Cov teebmeem ntawm hmoov Flibanserin (167933-07-5)

Cov txheej txheem phiv muaj feem ntau yog cov poj niam noj cov hmoov flibanserin hmoov. Feem ntau ntawm cov txheej xwm kev mob tshwm sim muaj me ntsis mus rau ib nrab. Feem ntau cov kev tshwm sim muaj xws li kiv taub hau, xeev siab, hnov ​​nkees, tsaug zog, thiab pw tsis tsaug zog.

Haus dej cawv thaum nyob ntawm flibanserin hmoov yuav ua rau tsis tshua muaj ntshav siab (tsis tshua muaj ntshav siab uas tshwm sim tom qab 2 tsom iav dej hauv 17%).


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1 xyuas rau Raw Flibanserin hmoov (167933-07-5)

  1. nyob 5 tawm ntawm 5

    phcoker -

    Tau Raw Flibanserin hmoov los mus kuaj, kuaj tau pom zoo heev thiab zoo!

Ntxiv ib tug saib xyuas

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Shangke Tshuaj yog ib lub tuam txhab muaj kev lag luam siab tshwj xeeb hauv cov kws tshuaj (Intermediates) (APIs). Los tswj cov khoom kom zoo thaum lub caij ntau lawm, ntau cov kws ua haujlwm tshaj lij, cov khoom siv rau thawj qib thiab cov chaw soj ntsuam yog cov ntsiab lus tseem ceeb.

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