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Raw Tianeptine sodium ntsev hmoov (30123-17-2)

nyob 5.00 tawm ntawm 5 raws li nyob rau hauv 1 neeg ntsuam xyuas
(1 neeg saib xyuas)

Tianeptine sodium ntsev hmoov yog ib lub tricyclic compound, yog tus xaiv lub facilitator ntawm 5-HT (serotonin; sc-201146) uptake in vitro ....


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 25kg / Nruas
Peev Xwm: 1290kg / hli

Hauj lwm

Raw Tianeptine sodium ntsev hmoov (30123-17-2) video

Raw Tianeptine sodium ntsev hmoov (30123-17-2) Specifications

khoom npe Raw Tianeptine sodium ntsev hmoov
Tshuaj Npe Tshuaj Tianeptine sodium; Tianeptine sodium ntsev; 30123-17-2; Stablon; Coaxil;
Hom NAme N / A
Chav Kawm Tshuaj N / A
CAS Number 30123-17-2
Hauv Chikey HNTRDGDHBBFLPG-UHFFFAOYSA-M
molecular Formula C21H24ClN2NaO4S
molecular Wyim 458.93
Monoisotopic pawg 458.104 g / mol
Melting Point 1800C
Boiltej no Point 609.2 ° C ntawm 760 mmHg
Loj Ib Nrab Ntawm Ib Leeg N / A
xim Dawb rau hmoov zoo dawb
Solubility DMSO: ≥20mg / mL
Snkauj Thuab cua Desiccate ntawm RT
Application Tianeptine sodium ntsev hmoov yog ib ntsev ntawm Tianeptine.

Tianeptine yog antidepressant.

Raw Tianeptine sodium ntsev hmoov (30123-17-2) Nqe lus piav qhia

Tianeptine sodium ntsev yog ntsev ntawm Tianeptine. Tianeptine, tricyclic compound, yog tus xaiv lub facilitator ntawm 5-HT (serotonin; sc-201146) uptake nyob rau hauv vitro thiab vivo. Tsis tas li ntawd, Tianeptine yog qhia ua ib qho kev xaiv ua rau cov neeg mob dopamine nce thiab zoo ib yam li amineptine. Tianeptine tsis muaj cov nyhuv rau cov tshuaj monoamine. Nyob rau hauv kev tshawb nrhiav kev siv dawb huv synaptosomes ntawm lub paj hlwb, Tianeptine tau qhia txog kev txhim kho serotonin uptake hauv cheeb tsam lub hlwb xaiv. Cov khoom sib tov ua ke tau txais los ntawm cov nas thiab muab cov tritium-labeled 5-HT thiab Tianeptine hauv vitro. Tus synaptosomes ces analyzed rau uptake thiab tso tawm 5-HT ntawm lub txee kua nplua.

Raw Tianeptine sodium ntsev hmoov yog lub atypical antidepressant nrog cov yeeb yam ntau, feem ntau notably ntawm cov glutamatergic.Nws attenuates glutamate tawm thiab modulates cov kev ua ntawm AMPA receptor.Tianeptine kuj ua raws li tus agonist ntawm cov tshuaj pleev (EC50s = 194 thiab 641 nM rau tib neeg thiab nas lub tswv yim, feem). Nws zoo ib yam li cov tshuaj fluoxetine nyob rau hauv kev tswj cov teeb meem tom qab ntxhov siab.

Tianeptine sodium ntsev tsis muaj lub peev xwm tsis muaj hauv kev xav txog cov neeg uas nws qhov kev paub txog yog qhov cuam tshuam los ntawm kev mob siab rau lub cev thiab muaj peev xwm los txhim kho kom pom tseeb thiab ua kom zoo rau cov tib neeg uas tsis tshua tau saib xyuas zoo li.

Tianeptine sodium ntsev hmoov (30123-17-2) Mechanism of Action

Cov kev tshawb fawb tsis ntev los no tau qhia tias tianeptine ua raws li kev hnyav tag nrho ntawm cov hom mob hu ua opioid opioid (MOR). Tianeptine tau tawm tsam teeb meem ntawm monoaminergic kev xav ntawm kev nyuaj siab, thiab cov txheej txheem kev txhawb siab monoaminergic uas muaj qhov kev txiav txim ntawm cov paub ntau tshaj antidepressants tau piav qhia. Tshwj xeeb, cov tshuaj no yog xav kom pheej hloov glutamate receptor bursting ntawm hippocampal CA3 commissural chaw ua haujlwm synapse. Kev tshawb nrhiav tam sim no qhia tias tianeptine ua rau nws cov teebmeem kev tiv thaiv antidepressant los ntawm kev hloov cov glutamate receptor kev ua si (piv txwv li, AMPA receptors thiab NMDA receptors) thiab cuam tshuam qhov kev tso tawm ntawm lub hlwb tawm ntawm cov hlwb neurotrophic (BDNF), uas raug cov neural yas. Ntau cov kev tshawb fawb los ntawm kev txhawb nqa lub luag hauj lwm ntawm tianeptine hauv kev hloov cov txheej txheem glutaminergic hauv amygdala, thaj tsam kev xav ntawm lub paj hlwb uas muaj kev nco.

Tianeptine txo cov lus teb rau hypothalamic-pituitary-adrenal rau kev ntxhov siab, thiab yog li tiv thaiv kev txhawj xeeb txog kev coj tus cwj pwm. Nyob rau hauv cov nas, cov kev ntxhov siab ntawm txoj kev khwv tsis yooj yim ua rau cov theem ntawm glutamate glutamate nyob rau hauv basolateral amygdala cov nyhuv uas inhib los ntawm tianeptine. Interestingly, lub SSRI fluoxetine ntau ntxiv cov kab mob extracellular glutamate nyob rau hauv basolateral amygdala tsis hais txog kev ntxhov siab li cas. Cov ntaub ntawv no qhia tias cov mechanism ntawm kev txiav txim ntawm tianeptine yog txawv ntawm SSRIs thiab txhawb qhov kev taw qhia tias qhov kev txiav txim siab ntawm kev txiav txim ntawm tianeptine ntsig txog kev hloov ntawm glutaminergic kev ua si hauv amygdala thiab hippocampus.

Ntxiv nrog rau cov mechanisms saum toj no, tianeptine yog ib qho kev kho antidepressant thiab anxiolytic tshuaj uas ua rau cov kev mob siab ntawm serotonin (5-hydroxytryptamine; 5-HT), thiab 5-hydroxyindoleacetic acid (5-HIAA) nyob rau hauv lub paj hlwb.

Txawm hais tias cov monoaminergic neurotransmitters serotonin (5-HT), noradrenaline (NA) thiab dopamine (DA) muaj qhov tseeb txog qhov tshwm sim ntawm kev nyuaj siab, nws yog tam sim no lees paub tias monoamine tsis txaus los piav qhia txog qhov kev txiav txim ntawm qhov kev txiav txim siab ntawm antidepressant tshuaj.

cov kev pab cuam of Tianeptine sodium ntsev hmoov (30123-17-2)

  • Tianeptine sodium ntsev tuaj yeem kho tus mob nyuab siab heev.
  • Tianeptine sodium ntsev muaj kev ntxhov siab thiab tshuaj tua kab mob thiab tshuaj tua tsis zoo.
  • Tianeptine sodium ntsev ua kom zoo siab thiab txhim kho kev mob hlwb.
  • Tianeptine sodium ntsev ua rau tuaj yeem thaiv kev tawm tsam ntawm kev tshwm sim.
  • Tianeptine sodium ntsev kho mob mob nrog fibromyalgia.
  • Tianeptine sodium ntsev siv nyob rau hauv kev kho mob ntawm kev nyuaj siab rau cov txiv neej nrog erectile kawg.
  • Tianeptine sodium ntsev muaj ntsis ua rau ADHD.
  • Tianeptine sodium ntsev kuj txhawb nqa neuroplasticity.

pom zoo Tianeptine sodium ntsev hmoov (30123-17-2) Dosage

Tianeptine Sodium muaj luv luv ib nrab ntawm lub neej nyob ntawm 2.5 xuab moos 14, thiab yuav tsum tau txhaj ob zaug rov qab txhua hnub. Tianeptine sodium dosage yog 12.5 mg noj peb zaug ib hnub, rau tag nrho 37.5mg ib hnub twg.

Tsis pub tshaj 50mg ntawm Tianeptine Sodium hauv ib hnub. Ua li ntawd yuav qhib qhov rooj rau kev tsim txom thiab kev muaj peev xwm ntxiv.

Sab los ntawm Tianeptine sodium ntsev hmoov (30123-17-2)

Tianeptine sodium ntsev hmoov sib xyaw ua ke nrog ntau qhov chaw ntawm lub hlwb nrog rau opiod receptors, uas muaj peev xwm tsim cov nyhuv sab ntawm kev zoo siab. Lwm cov kev mob tshwm sim nrog ntau zaus muaj xws li hauv qab no:

Mob taub hau (mus txog 18%)

Kiv taub hau (txog 10%)

Insomnia / night terrors (mus txog 20%)

Tsaus muag (txog 10%)

Qhov ncauj qhuav (txog 20%)

Lwm cov kev mob tshwm sim muaj xws li cem quav, xeev siab, kev ntxhov siab lossis mob toxicity. Kev txhawj txog teeb meem loj muaj xws li tshem tawm tom qab kev tsim txom thiab kwv yees li 0.1 - 0.3% ntawm cov neeg siv yuav muaj qhov teeb meem no. Ua li puas tau, raws li koj tau pom, cov kev mob tshwm sim ntawm Tianeptine sodium ntsev yuav mus nyob ntawm seb tus neeg thiab nws tus kheej biochemistry.

Nws yog tsim nyog sau cia tias:

Cov neeg laus yuav tsum noj tsawg dua ntawm Tianeptine sodium ntsev, zoo li cov neeg mob uas tsis ua haujlwm hla. Kev siv tshuaj tsis tas yuav kho rau cov neeg mob uas muaj kev quav dej quav cawv los yog cov neeg mob xiam oob qhab, lossis cov neeg mob ntawm kev lim ntshav .Txawm Antidepressants, zoo li tianeptine, ntau dua qhov muaj kab mob toxicity.


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1 xyuas rau Raw Tianeptine sodium ntsev hmoov (30123-17-2)

  1. nyob 5 tawm ntawm 5

    phcoker -

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