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Monotetrahexosylganglioside Sodium (GM1) npua hlwb (37758-47-7)

nyob 5.00 tawm ntawm 5 raws li nyob rau hauv 1 neeg ntsuam xyuas
(1 neeg saib xyuas)

GM1 hmoov tau dav siv los kho neonatal hypoxic-ischemic hlwb raug, Parkinson tus kab mob ... ..


raws li txoj cai: Hauv Pawg Ntau Lawm
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Peev Xwm: 1277kg / hli

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Monotetrahexosylganglioside Sodium (GM1) npua lub hlwb (37758-47-7) yees duab

Monotetrahexosylganglioside Sodium (GM1) npua lub hlwb (37758-47-7) Nqe lus piav qhia

Monotetrahexosylganglioside Sodium (GM1) npua lub hlwb (lub npe 37758-47-7), lub npe luv yuav ua tau GM1, muab rho tawm los ntawm tus npua lub hlwb thiab yog ib tug tub koom xeeb ntawm gangliosides uas muaj ib qho sialic acid residue.

GMl tuaj yeem txhawb kev rov qab los ntawm kev ua haujlwm ntawm cov hlab ntsha tom qab raug mob ntawm lub hauv siab ntsig system ntawm ntau yam ua rau, txhawb nqa neuroplasticity. Kev ntsuam xyuas qhia tias GMI vascular hlwb raug mob, lub hlwb traumatic los kho cov hlab ntsha hauv qaum txha raug mob muaj kev tiv thaiv thiab txhawb lub luag haujlwm ntawm tes.

Yav dhau los theem II soj ntsuam sim, nws yuav txo tau oxaliplatin induced neurotoxicity (OIN). Tab sis nws tsis muaj ntawv pov thawj los ntawm theem III sim. Ib qho kev ntsuam xyuas theem III yog xav tau los mus tshawb xyuas cov nyhuv thiab kev nyab xeeb ntawm monotetrahexosylganglioside Sodium Txhaj rau kev tiv thaiv OIN ntawm kev mob plaw.

Monotetrahexosylganglioside Sodium (GM1) npua lub hlwb (37758-47-7) Specifications

khoom npe Monotetrahexosylganglioside Sodium (GM1) npua lub hlwb
Tshuaj Npe Tshuaj Monotetrahexosylganglioside Sodium (Porcine lub hlwb)

Los yog GM1

ib theem zuj zus /
Hom NAme Shenjie
Chav Kawm Tshuaj Sphingolipids
CAS Number 37758-47-7
Hauv Chikey GTTLZSUWCRJZRC-CRQBLQEMSA-N
molecular Formula C73H134N4O31
molecular Wyim 1563.85
Monoisotopic pawg 1563.85
Melting Point N / A
Loj Ib Nrab Ntawm Ib Leeg /
xim Tawm-dawb lyophilized hmoov
solubility chloroform / methanol (9: 1): 10 mg / mL, ntshiab, tsis muaj xim
cia Thuab cua -20 ° C
Application Cov kws kho mob tshwj xeeb rau cov kab mob toxin uas txuam rau hauv lub hlwb hauv lipidosis thaum yav tom ntej.
Cov khoom sib tw Hauv tsev zoo qauv
Chakab mob Dawb los yog hmoov hmoov; me ntsis tsis hnov ​​tsw, tsis muaj dab tsi; ntub. Cov khoom no yog nyob hauv cov dej, muaj me ntsis yaj hauv methanol, yuav luag tsis muaj nyob rau hauv anhydrous ethanol.
Identification
Xim rov tom qab 1 Siv 0.2ml raws li kev txiav txim siab, ntxiv dej 2ml, thiab ntxiv rau Hydroquinone hydrochloric acid solution (hydroquinone 0.2g, ntxiv dej 10ml yaj, ntxiv cov hydrochloric acid 90ml, ntxiv 0.1mol / L Copper sulfate solution 0.25ml, yees txuag) 2ml, dej da dej sov so rau 15 feeb, xiav xim liab, nrog rau cov dej cawv 5ml Kev Tshawb Fawb, tsis haus dej cawv txheej xiav.
Xim rov tom qab 2 Noj cov khoom no txog 20mg, ntxiv cov dej qab ntu acetic acid 1ml, dej kub da dej cua sov cua txias tag nrho, ntxiv rau peb lub raj dej xoom 1, hauv cov dej kub da dej raws cov yeeb nkab phab ntsa ntxiv rau sulfuric acid 1ml, , ob-kua interface yuav tsum muaj xim av
Sodium ntsev Cov tshuaj tiv thaiv ntawm sodium ntsev hauv cov khoom no (suav Pharmacopoeia 2015 tsab plaub 0301).
Cov kua chromatography (LC) Hauv cov chromatographic teeb uas tau sau tseg hauv cov ntsiab lus txiav txim siab, lub sij hawm ncua ntawm lub ntsiab ntawm qhov kev tshuaj ntsuam yuav tsum ua raws nraim nrog lub sij hawm ncua ntawm lub ntsiab ntawm qhov kev tswj kav.
Infrared spectroscopy Daim duab qhia lub thev duab ntawm lub thev duab no yuav tsum muaj raws li daim ntawv qhia kev tswj khoom (suav Pharmacopoeia 2015 tsab plaub 0402).
Tshawb xyuas
PH 5.0 ~ 6.5
Clarity thiab xim ntawm cov kua Yuav tsum tau qhia tsis meej; Yog tias nws yog pos huab, nws yuav tsum tsis txhob hnyav dua li tus qauv kua ntawm turbidity Tsis 1th; Yog hais tias cov xim rendering yuav tsum tsis ntxaum dua Xim No. 1th colorimetric tov.
Kev Txiav Txim Siab Siab Cov tshuaj tiav lawm yuav tsum tau meej thiab tsis tshua tom qab kub, tsis muaj mis nyuj, tsis muaj nag lossis daus
Qhov muaj feem cuam tshuam txog (Lwm yam protein ntau) ≤50000
Tag Nrho Sialic acid Raws li cov khoom tsim tawm, cov qaub ncaug uas muaj acid yuav tsum yog 19.0 ~ 21.0%
lwm yam tshuaj Sialic acid ≤0.3%; GD3, GD1a, tsis paub txwv impurities yog ≤ 0.5%; impurities thiab ≤2.0%
protein ≤1.0%
High molecular hnyav impurities ≤0.5%
Residual solvents Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤ 0.003%
dej ≤4.0%
Hlawv seem ≤5.0%
Hnyav hlau ≤20ppm
Hloov kom tsis muaj kab mob Txhim Kho Cov Cai
Antihypertensive tshuaj Yuav tsum ua raws li cov cai (ntau ntau ntawm cov thawj coj)
Pyrogen Yuav tsum ua raws li cov cai (ntau ntau ntawm cov thawj coj)
Microbial txwv Tag nrho cov kab mob aerobic yuav tsum yog <100cfu / g, thiab tag nrho cov molds thiab yeasts yuav tsum <50cfu / g
Kev ≥98.0%

Nyoo MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) hmoov (37758-47-7) Qhia

Monotetrahexosylganglioside Sodium (37758-47-7), lub npe luv yuav ua tau GM1, muab rho tawm los ntawm tus npua lub hlwb thiab yog ib tug tub koom xeeb ntawm gangliosides uas muaj ib qhov chaw sialic acid.

GM1 tuaj yeem txhawb kev rov qab los ntawm kev ua haujlwm ntawm cov hlab ntsha tom qab raug mob ntawm lub hauv siab hauv nruab nrab ntawm cov hlab ntsha ntawm ntau yam ua rau, txhawb nqa neuroplasticity. Kev ntsuam xyuas qhia tias GM1 vascular hlwb raug mob, lub hlwb puas tsuaj rau cov hlab ntsha hauv qaum txha raug mob muaj kev tiv thaiv thiab txhawb txoj haujlwm ntawm tes.

Yav dhau los theem II soj ntsuam sim, nws yuav txo tau oxaliplatin induced neurotoxicity (OIN). Tab sis nws tsis muaj ntawv pov thawj los ntawm theem III sim. Ib qho kev ntsuam xyuas theem III yog xav tau los mus tshawb xyuas cov nyhuv thiab kev nyab xeeb ntawm monotetrahexosylganglioside Sodium Txhaj rau kev tiv thaiv OIN ntawm kev mob plaw.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) hmoov (37758-47-7) Mechanism kev ua?

GM1 (monotetrahexosylganglioside) "prototype" ganglioside, yog ib tug tswv cuab ntawm lub ganglio series ntawm gangliosides uas muaj ib qhov chaw sialic acid. GM1 muaj qhov tseem ceeb hauv lub cev thiab muaj kev cuam tshuam cov hlwv thiab kho cov khoom kho, thiab tso tawm cov neurotrophins hauv lub hlwb. Dhau li ntawm nws cov kev ua haujlwm nyob rau hauv lub cev ntawm lub hlwb, GM1 ua raws li lub vev-xaij rau cov kab mob toxin thiab E. coli tshav kub hnyuv ntxwm enterotoxin (Traveler's Diarrhea).

cov kev pab cuam of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) hmoov (37758-47-7)

Ganglioside GM1 yog ib tug tswv cuab ntawm tsev neeg ganglioside uas tau siv ntau lub teb chaws thiab xav tias yog lwm txoj kev kho mob kom tiv thaiv tau ntau hom kab mob kev nyuab siab, nrog rau kev mob txeeb ntawm cerebral ischemic. Cov teebmeem kho mob ntawm GM1 tau ua pov thawj ob leeg hauv cov neonates thiab cov neeg laus tom qab lub ischemic brain puas lawm.

pom zoo MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) hmoov (37758-47-7) Feem ntau

Cov tshuaj no tau txhaj tshuaj ntawm 20-40 mg txhua txhua hnub los ntawm kev txhaj tshuaj los yog qeeb intramuscular raws li tus kws kho mob cov lus qhia. Hauv cov kab theem pib ntawm kev hloov cov qoob loo: Tshuaj siv los ntawm koob tshuaj 100 txhua txhua hnub los ntawm kev txhaj tshuaj; Tom qab 2-3 lub lis piam, feem ntau tswj hwm tus nqi 20-40 mg txhua hnub rau 6 lub lis piam, thawj koob tshuaj 500-1000 mg tau raug tso los ntawm cov tshuaj tua kab mob rau cov kab mob Parkinson; txij li ob hnub, tshuaj siv nrog koob tshuaj 200 txhua hnub los ntawm subcutaneous, intramuscular txhaj tshuaj los yog tso kua dej tawm rau 18 lub lis piam feem ntau. thaum siv tshuaj los ntawm Subcutaneous los yog intravenous txhaj, nws yuav tsum tau yaj thiab diluted hauv dej rau kev txhaj tshuaj kom txog rau thaum cov concentration ntawm 10 mg / ml ntawm tus neeg thaum siv tshuaj tua kab, tshuaj raug tsis zoo thiab diluted hauv 0.9% sodium chloride injection los yog 5% koob txhaj tshuaj.

Sab los of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) hmoov (37758-47-7)

Cov nyhuv ntawm GM1 hmoov yog cov tshuaj tua kab mob tom qab siv tas li.


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References & cov khoom citations

1 xyuas rau Monotetrahexosylganglioside Sodium (GM1) npua hlwb (37758-47-7)

  1. nyob 5 tawm ntawm 5

    admin -

    Tau Monotetrahexosylganglioside Sodium (GM1) npua lub hlwb (37758-47-7) los kuaj, kuaj tau qhia tau zoo heev thiab purity!

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