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Raw Galantamine Hydrobromide hmoov (69353-21-5)

nyob 5.00 tawm ntawm 5 raws li nyob rau hauv 1 neeg ntsuam xyuas
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Galantamine Hydrobromide hmoov yog lub cholinesterase inhibitor uas tau siv rov qab ......


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 25kg / Nruas
Peev Xwm: 1290kg / hli

Hauj lwm

Raw Galantamine Hydrobromide hmoov (69353-21-5) video

Raw Galantamine Hydrobromide hmoov (69353-21-5) Hauj lwm

Raw Galantamine Hydrobromide hmoov yog ib tug benzazepine muab los ntawm norbelladine. Nws tau pom nyob hauv GALANTHUS thiab lwm yam AMARYLLIDACEAE. Nws yog ib tug cholinesterase inhibitor uas tau muab siv los hloov cov nqaij npaws ntawm GALLAMINE TRIETHIODIDE thiab TUBOCURARINE thiab tau kawm txog kev kho mob ALZHEIMER DISEASE thiab lwm yam kev mob hauv lub cev.

Raw Galantamine Hydrobromide hmoov yog lub hydrobromide ntsev daim ntawv ntawm galantamine, ib qho koob tshuaj tiv thaiv tertiary tau synthetically los yog ib txwm los ntawm cov qij thiab paj ntawm Narcissus thiab ntau lwm yam ntawm Amaryllidaceae tsev neeg nrog anticholinesterase thiab neurocognitive-enhancing kev ua ub no. Galantamine competitively thiab reversibly inhibits acetylcholinesterase, ua li ua qhov concentration thiab mus pab tau txoj haujlwm ntawm acetylcholine (Ach). Ntxiv mus, galantamine yog ligand rau nicotinic acetylcholine receptors, uas tej zaum yuav ua rau kom cov tshuaj tso tawm ntawm Ach thiab qhib cov qoob pob kabmob postynaptic. Tus neeg sawv cev no tuaj yeem txhim kho kev ua haujlwm rau lub cev tsis muaj zog thiab mob Alzheimer tus kabmob thiab tejzaum yuav txo tau cov kev mob tshwm sim tsis zoo uas tsim los txhawb kev haus luam yeeb rov qab.

Raw Galantamine Hydrobromide hmoov (69353-21-5) Specifications

khoom npe Raw Galantamine Hydrobromide hmoov
Tshuaj Npe Tshuaj Galantamin; Galantamine; Galanthamine
Galanthamine Hydrobromide; Lycoremine; Nivalin
Nivaline; Razadyne; Reminyl
Galanthamine hydrobromide; Raw Galantamine Hydrobromide hmoov; 1953-04-4; Reminyl; Galanthamine (hydrobromide);
Hom NAme Tsis muaj cov ntaub ntawv muaj
Chav Kawm Tshuaj Alzheimer Disease Agents, cholinesterase inhibitor
CAS Number 69353-21-5
Hauv Chikey QORVDGQLPPAFRS-XPSHAMGMSA-N
molecular Formula C17H22BrNO3
molecular Wyim 368.271 g / mol
Monoisotopic pawg 367.078 g / mol
Melting Point 126-127 deg C
Cia kom khov Point Tsis muaj cov ntaub ntawv muaj
Loj Ib Nrab Ntawm Ib Leeg Ntaus ib nrab neej: 7 teev
xim Dawb khoom
Solubility Muab cov dej sov ua kom haum zoo; dawb do soluble hauv cawv, acetone, chloroform. Tsawg tsawg hauv benzene, ether.
Snkauj Thuab cua -20 ° C
Application cholinesterase inhibitor; tshuaj

Nyoo Galantamine Hydrobromide hmoov (69353-21-5) Qhia

Galantamine Hydrobromide yog hom hydrobromide ntsev ntawm galantamine, ib qho dej siab zoo dua qub los ntawm cov qij thiab paj ntawm Narcissus thiab ntau lwm yam ntawm Amaryllidaceae tsev neeg nrog anticholinesterase thiab neurocognitive-enhancing kev ua ub no. Galantamine competitively thiab reversibly inhibits acetylcholinesterase, ua li ua qhov concentration thiab mus pab tau txoj haujlwm ntawm acetylcholine (Ach). Ntxiv mus, galantamine yog ligand rau nicotinic acetylcholine receptors, uas tej zaum yuav ua rau kom cov tshuaj tso tawm ntawm Ach thiab qhib cov qoob pob kabmob postynaptic. Tus neeg sawv cev no tuaj yeem txhim kho kev ua haujlwm rau lub cev tsis muaj zog thiab tsis meej Alzheimer tus kabmob thiab tejzaum yuav txo tau cov kev mob uas tsis to taub-uas yog kev paub txog kev haus luam yeeb uas txhawb kev haus luam yeeb rov qab.

Galantamine Hydrobromide hmoov (69353-21-5) Mechanism of Action?

Galantamine yog alkaloid phenanthrene thiab ib reversible, sib tw acetylcholinesterase inhibitor. Nws tsis yog structurally txog lwm yam acetylcholinesterase inhibitors. Galantamine lub tswv yim ntawm qhov kev txiav txim siab yuav ua rau cov khoom tsis haum ntawm acetylcholinesterase, uas tiv thaiv cov hydrolysis ntawm acetycholine, uas ua rau cov concentration ntawm acetylcholin ntawm cholinergic synapses. Galantamine tseem khi txhua yam nrog nicotinic acetylcholine receptors thiab tej zaum muaj peev xwm ua qhov kev txiav txim ntawm agonists (xws li acetylcholin) ntawm cov receptors.

cov kev pab cuam of Galantamine Hydrobromide hmoov (69353-21-5)

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pom zoo Galantamine Hydrobromide hmoov (69353-21-5) Feem ntau

Galantamine Hydrobromide hmoov 16 mg / hnub yog kev noj tshuaj rau cov neeg mob uas muaj mob me ntsis, zoo ib yam li cov tshuaj 24 mg / hnub. Txawm li cas los xij, cov neeg mob uas muaj ntsis AD tuaj mus tau txais txiaj ntsig ntxiv los ntawm galantamine 24 mg / hnub.

Sab los of Galantamine Hydrobromide hmoov (69353-21-5)

Cov kev mob tshwm sim ntawm Galantamine Hydrobromide hmoov muaj xws li nqaij ntshiv thiab tsis muaj zog, kev mob plawv, muaj teeb meem ntawm daim tawv nqaij, thiab tso zis tso quav. Noj cov tshuaj tiv thaiv kab mob siab ntsws tsis muaj zog hauv lub tsev Kalantas tseem ua rau kev npau taws thiab ntxhov siab.

Ntxiv rau cov teebmeem no, Galantamine txoj kev nrog lwm cov tshuaj yuav ua rau muaj mob. Nws raug qhia kom txo tau cov kev siv ntawm Galantamine thaum noj lwm hom tshuaj uas metabolised ntawm tib lub siab txoj sia (hepatic cytochrome system).

Thankfully, feem ntau ntawm cov kev mob tshwm sim saum no muaj tsawg thiab tej zaum yuav zam tau nrog cov paub tab paub xav.


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  1. nyob 5 tawm ntawm 5

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