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Raw Lorcaserin HCL hmoov (846589-98-8)

nyob 5.00 tawm ntawm 5 raws li nyob rau hauv 1 neeg ntsuam xyuas
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Raw Lorcaserin hydrochloride hmoov yog ib tug serotonin 2C (5-HT2C) receptor agonist thiab tshuaj noj tshuaj uas txhawb nqa ....


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 25kg / Nruas
Peev Xwm: 1380kg / hli

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Raw Lorcaserin HCL hmoov (846589-98-8) video

Raw Lorcaserin HCL hmoov (846589-98-8) Specifications

khoom npe Raw Lorcaserin Hydrochloride hmoov
Tshuaj Npe Tshuaj Raw Lorcaserin HCL hmoov, Lorcaserin
Hom NAme BELVIQ
Chav Kawm Tshuaj 5-HT2C receptor inhibitor
CAS Number 846589-98-8
Hauv Chikey ITIHHRMYZPNGRC-QRPNPIFTSA-N
molecular Formula C11H15Cl2N
molecular Wyim 232.15
Monoisotopic pawg 231.058154899
Melting Point Tsis muaj cov ntaub ntawv muaj
Freezing Point Tsis muaj cov ntaub ntawv muaj
Loj Ib Nrab Ntawm Ib Leeg Ib nrab ntawm lub neej ntawm lorcaserin yog kwv yees li 11 cov sij hawm.Lorcaserin hmoov yog tshem tawm feem ntau ntawm cov zis (92%) thiab hauv cov quav (2.2%)
xim Dawb hmoov
solubility Dej Dej Cev: 0.0709 mg / mL
cia Thuab cua -20 ° C.
Application Serotonin 2C (HT2C) receptor agonist rau qhov hnyav.Kom cov zaub mov noj thiab txhawb nqa satiety

Raw Lorcaserin Hcl hmoov (846589-98-8) Nqe lus piav qhia

Raw Lorcaserin hydrochloride hmoov yog lub hydrochloride tau los ntawm cov tshuaj tiv thaiv ntawm lorcaserin hmoov nrog ib qho sib npaug ntawm hydrochloric acid. Siv ua cov tshuaj tiv thaiv kev rog. Lorcaserin hydrochloride yog ib lub 5HT2c receptor agonist qhia rau cov neeg laus uas muaj BMI ≥30, los yog cov neeg uas muaj BMI ≥27 thiab tsawg tshaj ib qhov hnyav xws li tawg, hom 2 ntshav qab zib los yog dyslipidemia.Lorcaserin Hydrochloride hmoov ua haujlwm los ntawm suppressing qab los noj mov thiab induces zoo nkaus li ntawm satiety, thiab xav tias kom tsis txhob muaj nag lossis daus ntawm cov kab mob plawv nres nrog rau kev ua rau 5-HT2B receptors, thaj chaw ntawm lub hlwb paub ua si lub luag dej num loj hauv kev tswj kev tshaib kev nqhis thiab khoom noj. Los ntawm activating cov receptors, Lorcaserin hydrochloride hmoov yuav txo tau cov zaub mov noj los ntawm kev tsis qab los noj mov thiab ua ib tus neeg zoo tag nrho txawm tias tom qab noj zaub mov tsawg dua qub. tau txais kev pom zoo hnub no los ntawm FDA hauv thaj av txiav txim tom qab 2 xyoo ntawm kev ntsuam xyuas.

Lorcaserin hydrochloride hmoov yog qhia tau tias yog ib qho kev pabcuam txo qis-calorie noj haus thiab muaj lub cev ua haujlwm rau cov neeg laus mob hnyav (BMI ntawm 30 kg / m2 lossis ntau dua) thiab cov neeg laus rog (BMI ntawm 27 kg / m2 lossis ntau dua) nrog rau yam tsawg ib qhov hnyav txog kev hnyav.

Lorcaserin hydrochloride hmoov yog siv ua ke nrog kev noj haus thiab kev ua si kom khaus kev rog. Nws qee zaum siv los kho cov kab mob uas muaj feem xyuam rau ntshav qab zib, ntshav siab, lossis ntshav siab.

Lorcaserin hydrochloride yuav tsis kho txhua yam mob lwm tus (xws li mob plawv, ntshav qab zib, ntshav siab). Noj tshuaj lwm yam tshuaj uas koj tus kws kho mob tau qhia kom kho cov mob no.

Lorcaserin Hcl hmoov (846589-98-8) Mechanism of Action

Txawm hais tias tus mechanism tsis paub meej, nws ntseeg tau tias yuav tsum ua rau kev xaiv 5-HT2C receptors nyob rau hauv cov anorexigenic pro-opiomelanocortin neurons hauv arcuate nucleus ntawm hypothalamus. Qhov no ua rau cov zaub mov tsawg tsawg thiab satiety los ntawm kev qhia tawm ntawm alpha-melanocortin stimulating hormone, uas ua rau melanocortin-4 receptors.

Lorcaserin hydrochloride hmoov ua hauj lwm los ntawm kev tswj kev noj qab haus huv - uas yog qhib lub hlwb receptors rau serotonin, ib tug neurotransmitter uas ua txoj kev xav ntawm satiety thiab siab. Txaus ntawm cov zaub mov yog tswj los ntawm satiety center, nyob rau hauv ventromedial nucleus ntawm hypothalamus thiab kev tshaib plab chaw nyob rau hauv lateral hypothalamus. Ntau cov kev nkag los ntawm cov chaw siab dua thiab txoj hnyuv tws hlais hauv nruab nrab ntawm cov keeb kwm nucleus, qhov twg ob hom neurons tswj zaub mov noj yog tam sim no. Ua ntej, cov khoom noj khoom haus kom txais tau stimulatory ua khoom noj uas muaj agrogi-ntsig txog protein ntau thiab neuropeptide Y; thiab ob, cov khoom noj khoom haus ua kom tsis muaj teeb meem pab pawg neeg uas muaj cov tshuaj cocaine thiab amphetamine tswj cov ntawv sau (CART) thiab pro-opiomelanocortin (POMC) neurons. POMC muaj 5-HT 2C receptors, uas yog thaum pib ua haujlwm tawm alpha-melanocyte-stimulating hormone (alpha-MSH) .Txoj kev mob hlwb thiab stimulatory neurons ntxiv tej yaam num paraventricular nucleus hauv hypothalamus. Paraventricular nucleus muaj melanocyte 4 receptors (MC4R) uas inhibits qab los noj tshuaj nyob rau hauv kev kho mob lorcaserin hydrochloride hmoov ua raws li Xaiv 5-HT 2C agonist ntawm POMC neurons, uas nyeg ua tawm ntawm alpha MSH. Ntxiv alphfa MSH ua rau MC4R hauv paraventricular nucleus hauv hypothalamus, ua rau kom txo tau qhov qab los noj mov. Hauv supratherapeutic doses, lorcaserin hydrochlorider kuj ua rau 5-HT 2B thiab 5-HT 2A receptors.

cov kev pab cuam ntawm Lorcaserin Hcl hmoov (846589-98-8)

  • Lorcaserin HCL hmoov yog ib qho 5-HT2C receptor agonist uas xav tias yuav txo cov khoom noj kom tsawg los ntawm hauv nruab nrab lub zog POMC. Lorcaserin HCL cov hmoov av:
  • Lorcaserin HCL hmoov yog siv ua ke nrog kev noj haus thiab ua si kom khaus kev rog.
  • Lorcaserin HCL hmoov yog qee zaum siv los kho cov kab mob uas muaj feem xyuam rau ntshav qab zib, ntshav siab, lossis ntshav siab.
  • Lorcaserin HCL hmoov yuav tsis kho txhua yam mob (xws li mob plawv, ntshav qab zib, ntshav siab).

Pom zoo Lorcaserin Hcl hmoov (846589-98-8) Dosage

Lorcaserin HCL hmoov tuaj nyob rau hauv daim ntawv tshuaj thiab siv npaum 1-2 zaug ib hnub, nrog lossis tsis noj mov. Lorcaserin yuav tsum siv nrog rau txo cov khoom noj thiab txo lub cev ua si.

Qhov hnyav ntawm lorcaserin hcl hmoov yog 10 mg muab los ntawm qhov ncauj ob zaug ib hnub. Lorcaserin tuaj yeem noj tsis tau txog kev noj mov. Lorcaserin hcl yuav tsum tsis ua haujlwm nyob hauv cov neeg mob uas tsis ua haujlwm kom tsawg kawg yog 5 qhov hnyav poob phaus ntawm lub limtiam 12 vim tias cov neeg mob no yuav tsis muaj kev phom sij ntxiv nrog kev kho mob.

Sab los ntawm Lorcaserin Hcl hmoov (846589-98-8)

Lorcaserin Hcl hmoov yog siv rau kev kho mob ntawm cov laus mob hauv kev laus nrog lub cev huab hwm coj lub cev (BMI) ntawm 30 los yog ntau dua (rog) raws li kev ntxiv rau qhov txo qis-calorie noj haus thiab ua si. Nws kuj raug pom zoo rau cov neeg laus uas siv BMI ntawm 27 lossis ntau dua (thawj rog) thiab cov uas muaj yam tsawg ib yam mob hnyav xws li ntshav siab (siab ntshav siab), lossis mob roj ntshav siab (dyslipidemia). Txawm li cas los xij, nws kuj yuav muaj qee cov kev mob tshwm sim. Raws li hauv qab no:

Tnws feem ntau mob tshwm sim:

  • -Headache,
  • -Neeg,
  • -Cov ntawv,
  • -Lawm,
  • -Qhov ncauj,
  • -Cov hnav, thiab
  • -Hypoglycemia (ntshav qab zib tsawg).

Lwm yam kev mob tshwm sim tsis zoo tiam sis muaj mob tshwm sim nrog lorcaserin muaj xws li:

  • -Heart valve teeb meem,
  • -Cov suab hauv los nco,
  • -Muab teeb meem,
  • -Txawm lossis xav txog kev tua tus kheej,
  • -Tsis muaj teeb meem loj,
  • -Koj plawv dhia,
  • -Tus poob rau hauv cov ntshav ntawm suav, thiab
  • -Yog nce nyob rau hauv lub hormone, prolactin.


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References & cov khoom citations

FDA Pom Zoo Lorcaserin HCL Rau Kev Kho Mob Kev Nyuaj Siab

References

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., li peb: Kev Nyab Xeeb Kev Nyuaj Siab ntawm Lorcaserin hauv Cov Neeg Mob Rog lossis Rog, Tus Tshiab Hais Phau Ntawv Qhia Txog Tshuaj Kho Mob, 2018
  2. Food and Drug Administration, Medications Target Lub Sij Hawm Ntev Lawm, Online, Luam tawm 17 Lub Xya Hli 2012
  3. Ashley Gustafson, Cammile King, Jose AR, National Center Rau Biotechnology Qhia, PMC Cov Lus, MediMedia, Tebchaws USA Lorcaserin (Belviq), Online, Cuaj hlis 2013

1 xyuas rau Raw Lorcaserin HCL hmoov (846589-98-8)

  1. nyob 5 tawm ntawm 5

    phcoker -

    Tau Raw Lorcaserin HCL hmoov los soj ntsuam, kuaj pom tau zoo heev thiab purity!

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Koj email chaw nyob yuav tsis tsum luam tawm. Yuav tsum tau teb cov cim *

Shangke Tshuaj yog ib lub tuam txhab muaj kev lag luam siab tshwj xeeb hauv cov kws tshuaj (Intermediates) (APIs). Los tswj cov khoom kom zoo thaum lub caij ntau lawm, ntau cov kws ua haujlwm tshaj lij, cov khoom siv rau thawj qib thiab cov chaw soj ntsuam yog cov ntsiab lus tseem ceeb.

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