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Raw Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5)

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Raw Lorcaserin hydrochloride hemihydrate hmoov yog ib .......


raws li txoj cai: Hauv Pawg Ntau Lawm
Chav: 25kg / Nruas
Peev Xwm: 1280kg / hli

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Raw Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5) video

Raw Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5) Specifications

khoom npe Raw Lorcaserin hydrochloride hemihydrate hmoov
Tshuaj Npe Tshuaj (R) -8-chloro-1-tetrahydro-2,3,4,5-methyl-1h-3-benzazepine hydrochloride hemihydrate (R) -8-chloro-2,3,4,5-methyl-1-1H-3-benzazepine hydrochloride hemihydrate;
Hom NAme Belviq
Chav Kawm Tshuaj 5-HT2C receptor inhibitor
CAS Number 856681-05-5
Hauv Chikey WRZCAWKMTLRWPR-VSODYHHCSA-N
molecular Formula C22H32Cl4N2O
molecular Wyim 482.31
Monoisotopic pawg 480.1268745
Melting Point Tsis muaj cov ntaub ntawv muaj
Freezing Point Tsis muaj cov ntaub ntawv muaj
Loj Ib Nrab Ntawm Ib Leeg Lorcaserin muaj ntshav ib nrab ntawm xNUMX cov xuab moos
xim Dawb hmoov
solubility Dej Dej Cev 0.0709 mg / mL
cia Thuab cua Tsis muaj cov ntaub ntawv muaj
Application Raw Lorcaserin hydrochloride hemihydrate hmoov siv los ua tshuaj tiv thaiv kev rog. Nws muaj lub luag haujlwm xws li kev noj qab haus huv kev noj qab haus huv thiab tus kab mob serotonergic.

Raw Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5) Nqe lus piav qhia

Lorcaserin hydrochloride hemihydrate hmoov yog ib qho hydrate uas yog daim ntawv hemihydrate ntawm lorcaserin hydrochloride. Siv ua cov tshuaj tiv thaiv kev rog. Nws muaj lub luag haujlwm xws li kev noj qab haus huv kev noj qab haus huv thiab tus kab mob serotonergic. Nws muaj ib tug lorcaserin hydrochloride.

Raw Lorcaserin hydrochloride hemihydrate hmoov yog siv los kho cov kab mob rog uas muaj roj cholesterol, ntshav siab, lossis hom 2 ntshav qab zib.

Lub FDA pom zoo Nyoos Lorcaserin hydrochloride hemihydrate hmoov rau cov neeg uas rog (nrog ib lub cev huab hwm coj index, los yog BMI, ntawm 30 los yog siab dua) los yog leej twg yog tus neeg rog (nrog ib tug BMI ntawm 27 los yog saum toj no) thiab kuj muaj tsawg kawg yog ib tug weight- ntsig txog kev mob nkeeg xws li Type 2 diabetes, ntshav siab los yog siab roj cholesterol.

Raw Lorcaserin hydrochloride hemihydrate hmoov ua hauj lwm los ntawm kev tswj kev noj qab haus huv - uas yog qhib lub hlwb receptors rau serotonin, ib tug neurotransmitter uas ua txoj kev xav ntawm kev sib raug zoo thiab siab. Serotonin tseem muaj kev koom tes hauv kev xav; ntau cov tshuaj antidepressant ua hauj lwm los ntawm kev tiv thaiv tus kab mob rov rau serotonin thiab ua kom lub hlwb tau txais cov dej hauv cov tshuaj. Cov kws tshawb fawb hauv Arena hais tias lawv cov tshuaj yog tsim los mus tshawb nrhiav cov kab mob tsuas yog siv rau kev noj mov.

Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5) Mechanism of Action

Lorcaserin ntseeg tias yuav txo tau cov zaub mov noj thiab txhawb satiety los ntawm kev xyuam xim ua 5-HT2C receptors rau anorexigenic pro-opiomelanocortin neurons nyob hauv hypothalamus. Lub tswv yim ntawm kev txiav txim siab tsis paub.

Lorcaserin ntawm qhov kev pom zoo txhua hnub kom xyaw ua ke nrog 5-HT2C receptors piv rau 5-HT2A thiab 5-HT2B receptors (saib Table 5), lwm 5-HT reseptor subtypes, 5-HT reseptor transporter, thiab 5-HT rov sau qhov chaw .

Daim ntawv thov ntawm Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5)

  • Kev xav noj qab haus huv: Tus neeg saib xyuas uas siv los txo txoj kev noj mov.
  • Serotonergic agonist: Tus neeg sawv cev uas muaj qhov affinity rau serotonin receptors thiab muaj peev xwm ntsig txog cov teebmeem ntawm serotonin los ntawm kev ua kom lub cev ua haujlwm hauv lub xov tooj ntawm tes. Serotonin agonists yog siv los ua antidepressants, anxiolytics, thiab kev kho mob ntawm cov mob migraine.

Pom zoo Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5)

Vim tias cov ntaub ntawv tseem ceeb ntawm kev siv cov tshuaj Lorcaserin hydrochloride hemihydrate tsis tuaj yeem pom, cov ntaub ntawv hauv qab no yog siv rau:

Lorcaserin HCL hmoov 846589-98-8 los ntawm daim ntawv xaj thiab tau noj 1-2 zaug ib hnub, nrog lossis tsis noj mov. Lorcaserin yuav tsum siv nrog rau txo cov khoom noj roj tsawg thiab ib qho kev npaj ua si.

Qhov hnyav tshuaj ntawm lorcaserin yog 10 mg muab los ntawm lub qhov ncauj ob zaug ib hnub. Lorcaserin tuaj yeem noj tsis tau txog kev noj mov. Lorcaserin yuav tsum tsis ua haujlwm nyob rau cov neeg mob uas tsis ua haujlwm kom tsawg kawg yog 5 qhov hnyav poob phaus ntawm lub limtiam 12 vim cov neeg mob no yuav tsis muaj kev phom sij ntxiv nrog kev kho mob ntxiv.

kev pab cuam ntawm Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5)

Lorcaserin hydrochloride hemihydrate hmoov yog ib qho 5-HT2C receptor agonist uas xav tias yuav txo cov khoom noj kom tsawg los ntawm central POMC system. Lorcaserin HCL cov hmoov av:

  • Lorcaserin hydrochloride hemihydrate hmoov yog siv ua ke nrog kev noj haus thiab kev ua si kom khaus kev rog.
  • Lorcaserin hydrochloride hemihydrate hmoov yog qee zaum siv los kho cov kab mob uas muaj feem xyuam rau ntshav qab zib, ntshav siab, lossis ntshav siab.
  • Lorcaserin hydrochloride hemihydrate hmoov yuav tsis kho txhua yam mob lwm tus (xws li mob plawv, ntshav qab zib, ntshav siab).

Sab los ntawm Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5)

Lorcaserin hydrochloride hemihydrate hmoov yog siv rau cov kev kho mob ntawm kev tswj cov nyhav laus hauv cov laus nrog lub cev huab hwm coj lub cev (BMI) ntawm 30 lossis ntau dua (rog) ua ntxiv rau qhov txo cov calorie noj thiab ce. Nws kuj raug pom zoo rau cov neeg laus uas siv BMI ntawm 27 lossis ntau dua (thawj rog) thiab cov uas muaj yam tsawg ib yam mob hnyav xws li ntshav siab (siab ntshav siab), lossis mob roj ntshav siab (dyslipidemia). Txawm li cas los xij, nws kuj yuav muaj qee cov kev mob tshwm sim. Raws li hauv qab no:

Tnws feem ntau mob tshwm sim:

  • -Headache,
  • -Neeg,
  • -Cov ntawv,
  • -Lawm,
  • -Qhov ncauj,
  • -Cov hnav, thiab
  • -Hypoglycemia (ntshav qab zib tsawg).

Lwm yam kev mob tshwm sim tsis zoo tiam sis muaj mob tshwm sim nrog lorcaserin muaj xws li:

  • -Heart valve teeb meem,
  • -Cov suab hauv los nco,
  • -Muab teeb meem,
  • -Txawm lossis xav txog kev tua tus kheej,
  • -Tsis muaj teeb meem loj,
  • -Koj plawv dhia,
  • -Tus poob rau hauv cov ntshav ntawm suav, thiab
  • -Yog nce nyob rau hauv lub hormone, prolactin.


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1 xyuas rau Raw Lorcaserin hydrochloride hemihydrate hmoov (856681-05-5)

  1. nyob 5 tawm ntawm 5

    phcoker -

    Tau txais Raw Lorcaserin hydrochloride hemihydrate hmoov mus ntsuam xyuas, kuaj tau qhia tau zoo heev thiab purity!

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Shangke Tshuaj yog ib lub tuam txhab muaj kev lag luam siab tshwj xeeb hauv cov kws tshuaj (Intermediates) (APIs). Los tswj cov khoom kom zoo thaum lub caij ntau lawm, ntau cov kws ua haujlwm tshaj lij, cov khoom siv rau thawj qib thiab cov chaw soj ntsuam yog cov ntsiab lus tseem ceeb.

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