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CRL-40,940 hmoov (90280-13-0)

CRL-40,940 (tseem hu ua flmodafinil, bisfluoromodafinil thiab lauflumide) yog cov analog ntawm modafinil hmoov, uas ......


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Raw CRL-40,940 hmoov (90280-13-0) video

Raw CRL-40,940 hmoov (90280-13-0) Hauj lwm

Raw CRL-40,940 hmoov (tseem hu ua flmodafinil, lauflumide, bisfluoromodafinil, thiab flmoda) yog ib hom kab hom ntawm modafinil, cov tshuaj tivthaiv ntse tshuaj siv los kho obstructive pw tsaug zog apnea, ua haujlwm tsis tsaug zog, ua haujlwm tsis tsaug zog, thiab ntau lub sijhawm pw tsaug zog.

CRL-40,940 hmoov yog molecule zoo ib yam li modafinil thiab adrafinil thiab tau qhia tias nws zoo dua li ob lub lwg me me hauv lawv cov cim nrog tsawg dua kev phiv. Nws yog ib lub koom haum txhawb zog tuaj siv rau kev kho mob xws li narcolepsy, ua haujlwm tsis tsaug zog, thiab pw tsaug zog ntev heev nrog kev pw tsaug zog apnea. Thaum kawg, nws yuav ua kom haum zoo Glutamate receptors zoo li uas yog theorized los ua lub ntsiab mechanism ntawm kev txiav txim siab tom qab cov kev paub ntawm cov yeeb tshuaj ntse. Nws kuj ua haujlwm los ntawm kev tiv thaiv kev rhuav tshem ntawm Dopamine, uas pab txhim kho txoj kev xav thiab txo cov kev ntxhov siab. Nws xav tau ntxiv los ua kom muaj kev tso tawm ntawm Serotonin uas tuaj yeem pab tswj tau pw tsaug zog zoo li muaj kev ntxhov siab tsawg.

CRL-40,940 hmoov (90280-13-0) Mechanism of Action

Tsis ntev tas los no CRL-40,940 hmoov yeej tau zoo lawm tias nws muaj peev xwm pab tau zoo dua li cov neeg tau txais kev kho mob tam sim no los ntawm psychostimulants, yuav kho cov tsos mob rau cov kev kho mob tam sim no uas tsis muaj cov tsos mob tshwm sim, thiab yuav muaj tshuaj lom tsawg.

CRL-40,940 hmoov yog molecule zoo ib yam li modafinil thiab adrafinil thiab tau qhia tias nws zoo dua li ob lub lwg me me hauv lawv cov cim nrog tsawg dua kev phiv. Nws yog ib lub koom haum txhawb zog tuaj siv rau kev kho mob xws li narcolepsy, ua haujlwm tsis tsaug zog, thiab pw tsaug zog ntev heev nrog kev pw tsaug zog apnea. Thaum kawg, nws yuav ua kom haum zoo Glutamate receptors zoo li uas yog theorized los ua lub ntsiab mechanism ntawm kev txiav txim siab tom qab cov kev paub ntawm cov yeeb tshuaj ntse. Nws kuj ua haujlwm los ntawm kev tiv thaiv kev rhuav tshem ntawm Dopamine, uas pab txhim kho txoj kev xav thiab txo cov kev ntxhov siab. Nws xav tau ntxiv los ua kom muaj kev tso tawm ntawm Serotonin uas tuaj yeem pab tswj tau pw tsaug zog zoo li muaj kev ntxhov siab tsawg

CRL-40,940 hmoov siv tau los txhim kho tub ntxhais kawm txoj kev nco thiab ua kom lawv lub siab paub. Sib piv nrog lwm cov neeg tsis muaj cuab kav ua rau kev kho mob rau ADHD thiab idiopathic hypersomnia tab sis tsis muaj tshuaj lom neeg tsawg tab sis tsis muaj kev tshawb fawb yuav ua pov thawj qhov kev thov no.

Daim ntawv thov CRL-40,940 hmoov (90280-13-0)

  • Ua kom muaj kev sib koom tes
  • Ua kom zoo dua mus ob peb vas
  • Pab sib ntaus sib tua
  • Txwv tsis pub oxidation nyob rau hauv lub hlwb
  • Kho cov dej cawv muaj feem xyuam paj hlwb

Pom zoo CRL-40,940 hmoov (90280-13-0) Dosage

Tsis muaj kev pom zoo rau kev noj tshuaj rau qhov no tiam sis raws li kev tshawb nrhiav thiab cov neeg siv 250-400 mg ib hnub thiab 100-200mgper hnub. Muab piv rau ob qhov kev siv, nws yog qhov zoo dua rau noj rau hauv qis dua rau thaum nws tau noj ntau dua li 250-400 mg, nws yuav tsim phiv nyhav tab sis rau 100-200mg, tsis muaj teebmeem tshwm sim.

Cov txiaj ntsig ntawm CRL-40,940 hmoov (90280-13-0)

  • Raws li tej kev tshawb fawb, nws yog ib tus Dr. Lafon, uas tau ua ke nrog lwm yam khoom xws li CRL 40929, CRL 40933, nws ua rau kev nrhiav pom tias yog ib qho tshuaj tua kab mob. Qhov no tau txais kev txhawb los ntawm cov lus nug nram qab no uas CRL 40 940 raug xam tias yog ib lub koom haum txhawb zog tuaj lossis ib tus tshiab eugeroic.
  • Raws li qee cov neeg siv, nws muaj zog tshaj li adrafinil thiab lawv kuj ua pov thawj tias nws pab tau rau hauv kev vam meej thiab kev ras txog tab sis kev ua siab ntev, tab sis tsis siab, yog tsim.
  • Piv rau Adrafinil, zoo li CRL-40 941, nws tsuas yog ib nrab ntawm adrafinil rau nws yog ob zaug ntxiv zog.
  • Hauv lwm qhov kev xeem siv cov nas loj, nws tau pom tias CRL 40 940 tau nce qib ntawm kev tsav tsheb.
  • Nws yog ib qho kev kho mob rau ADHD thiab idiopathic hypersomnia tab sis tsis muaj kuab lom tab sis tsis muaj kev tshawb nrhiav ntau yuav ua pov thawj qhov kev thov no.

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References & cov khoom citations

CRL-40,940 (Flmodafinil) Vs Modafinil: Dab tsi yog qhov sib txawv?

References

  1. Penaloza, RA Sarkar, U., Claman, DM, thiab Omachi, TA (2013). Hloov hauv Cov Ntawv Sau Npe thiab Tshawb Xo-Ntawv Modafinil Siv Hauv Tebchaws Sawv Cev Sawv Cev. JAMA Internal tshuaj.
  2. Mereu, M., Bonci, A., Newman, AH, thiab Tanda, G. (2013). Lub Neurobiology ntawm Modafinil yog ib qho Kev Cobphum ntawm Kev Ntsuas Ua Tau thiab Ib Yam Kev Kho Mob Rau Cov Khoom Uas Siv Tshuaj.
  3. Ballas, CA, Kim, D., Baldassano, CF, thiab Hoeh, N. (2002). Modafinil: Yav tag los, Tam sim no, thiab yav tom ntej.Kws Tshaj Tawm Txog Kev Kho Mob Neurotherapeutics.
  4. Eric Konofal. (2013). Patent US 20130295196 A1 - Lauflumide thiab Enantiomers Thereof, Txoj Kev Siv Npaj Tib thiab Siv Tshuaj Thoob Ntoo.
  5. Gerrad, P., thiab Malcolm, R. (2007). Mechanisms ntawm Modafinil: Kev Tshawb Fawb Txog Kev Tshawb Fawb Tam Sim No. Neuropsychiatric Disease and Treatment.

Xyuas

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Shangke Tshuaj yog ib lub tuam txhab muaj kev lag luam siab tshwj xeeb hauv cov kws tshuaj (Intermediates) (APIs). Los tswj cov khoom kom zoo thaum lub caij ntau lawm, ntau cov kws ua haujlwm tshaj lij, cov khoom siv rau thawj qib thiab cov chaw soj ntsuam yog cov ntsiab lus tseem ceeb.

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